ARHGAP27

Rho GTPase activating protein 27 is a protein that in humans is encoded by the ARHGAP27 gene. [5]

ARHGAP27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PP2
Identifiers
Aliases	ARHGAP27, CAMGAP1, PP905, SH3D20, SH3P20, Rho GTPase activating protein 27
External IDs	OMIM: 610591 MGI: 1916903 HomoloGene: 45715 GeneCards: ARHGAP27
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 45,393,902 bp[1] End 45,434,421 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 103,331,497 bp[2] End 103,363,692 bp[2]
Gene ontology Molecular function • SH3 domain binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Cellular component • intracellular • membrane • cell nucleus • nucleoplasm • cytoplasm • cytosol Biological process • endocytosis • signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • receptor-mediated endocytosis • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	201176	544817
Ensembl	ENSG00000159314 ENSG00000276836 ENSG00000276907	ENSMUSG00000034255
UniProt	Q6ZUM4 Q8N2Y9	A2AB59
RefSeq (mRNA)	NM_001159330 NM_001282290 NM_174919 NM_199282	NM_001205236 NM_133715 NM_183288
RefSeq (protein)	NP_001269219 NP_777579 NP_954976 NP_954976.1	NP_001192165 NP_598476 NP_899111
Location (UCSC)	Chr 17: 45.39 – 45.43 Mb	Chr 11: 103.33 – 103.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may play a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013].

References

1. ENSG00000276836, ENSG00000276907 GRCh38: Ensembl release 89: ENSG00000159314, ENSG00000276836, ENSG00000276907 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034255 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Rho GTPase activating protein 27". Retrieved 2018-05-30.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Rho GTPase-activating protein 27 (ARHGAP27)

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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