APBB2

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.[5][6][7]

APBB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WGU, 2ROZ, 2YSZ, 2YT0, 2YT1
Identifiers
Aliases	APBB2, FE65L, FE65L1, amyloid beta precursor protein binding family B member 2
External IDs	OMIM: 602710 MGI: 108405 HomoloGene: 32079 GeneCards: APBB2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p14-p13 Start 40,810,027 bp[1] End 41,216,714 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.1 Start 66,298,703 bp[2] End 66,618,784 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • transcription factor binding • amyloid-beta binding Cellular component • growth cone • membrane • cytoplasm • lamellipodium • synapse • cell nucleus Biological process • positive regulation of apoptotic process • GO:0007243 intracellular signal transduction • negative regulation of cell growth • negative regulation of apoptotic process • cell cycle arrest • extracellular matrix organization • axon guidance • neuron migration • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	323	11787
Ensembl	ENSG00000163697	ENSMUSG00000029207
UniProt	Q92870	Q9DBR4
RefSeq (mRNA)	NM_001166050 NM_001166051 NM_001166052 NM_001166053 NM_001166054 NM_004307 NM_173075 NM_001330656 NM_001330658	NM_001201413 NM_001201414 NM_001201415 NM_001201416 NM_009686 NM_001310626
RefSeq (protein)	NP_001159522 NP_001159523 NP_001159524 NP_001159525 NP_001159526 NP_001317585 NP_001317587 NP_004298 NP_775098	NP_001188342 NP_001188343 NP_001188344 NP_001188345 NP_001297555 NP_033816
Location (UCSC)	Chr 4: 40.81 – 41.22 Mb	Chr 5: 66.3 – 66.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000163697 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029207 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McLoughlin DM, Miller CC (Jan 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. 397 (2–3): 197–200. doi:10.1016/S0014-5793(96)01128-3. PMID 8955346.
6. Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM (Jun 1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm Genome. 9 (6): 473–5. doi:10.1007/s003359900800. PMID 9585438.
7. "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)".

External links

• Human APBB2 genome location and APBB2 gene details page in the UCSC Genome Browser.

Further reading

• Guénette SY, Chen J, Jondro PD, Tanzi RE (1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10832–7. doi:10.1073/pnas.93.20.10832. PMC 38241. PMID 8855266.
• Bruni P, Minopoli G, Brancaccio T, et al. (2002). "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression". J. Biol. Chem. 277 (38): 35481–8. doi:10.1074/jbc.M205227200. PMID 12089154.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chang Y, Tesco G, Jeong WJ, et al. (2004). "Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1". J. Biol. Chem. 278 (51): 51100–7. doi:10.1074/jbc.M309561200. PMID 14527950.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Li Y, Hollingworth P, Moore P, et al. (2006). "Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease". Hum. Mutat. 25 (3): 270–7. doi:10.1002/humu.20138. PMID 15714520.
• Lange A, Thon L, Mathieu S, Adam D (2005). "The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor". Biochem. Biophys. Res. Commun. 335 (2): 575–83. doi:10.1016/j.bbrc.2005.07.125. PMID 16083851.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Hong Q, Hsu LJ, Schultz L, et al. (2007). "Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response". BMC Mol. Biol. 8: 50. doi:10.1186/1471-2199-8-50. PMC 1904229. PMID 17567906.