APBA2BP

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.[5][6]

NECAB3
Identifiers
Aliases	NECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium binding protein 3
External IDs	OMIM: 612478 MGI: 1861721 HomoloGene: 10992 GeneCards: NECAB3
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 33,657,087 bp[1] End 33,674,463 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 154,544,399 bp[2] End 154,558,890 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • GO:0001948 protein binding • metal ion binding Cellular component • cell nucleus • cytoplasm • endoplasmic reticulum membrane • endoplasmic reticulum • Golgi cis cisterna • Golgi apparatus Biological process • protein secretion • protein metabolic process • regulation of amyloid precursor protein biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	63941	56846
Ensembl	ENSG00000125967	ENSMUSG00000027489
UniProt	Q96P71	Q9D6J4
RefSeq (mRNA)	NM_031231 NM_031232	NM_021546 NM_001379147 NM_001379148 NM_001379149
RefSeq (protein)	NP_112508 NP_112509	NP_067521 NP_001366076 NP_001366077 NP_001366078
Location (UCSC)	Chr 20: 33.66 – 33.67 Mb	Chr 2: 154.54 – 154.56 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000125967 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027489 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee DS, Tomita S, Kirino Y, Suzuki T (Aug 2000). "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein". J Biol Chem. 275 (30): 23134–8. doi:10.1074/jbc.C000302200. PMID 10833507.
6. "Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein".

External links

• Human NECAB3 genome location and NECAB3 gene details page in the UCSC Genome Browser.

Further reading

• Büssow K, Cahill D, Nietfeld W, et al. (1998). "A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library". Nucleic Acids Res. 26 (21): 5007–8. doi:10.1093/nar/26.21.5007. PMC 147919. PMID 9776767.
• Sugita S, Südhof TC (2000). "Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins". Biochemistry. 39 (11): 2940–9. doi:10.1021/bi9920984. PMID 10715114.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Sugita S, Ho A, Südhof TC (2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern". Neuroscience. 112 (1): 51–63. doi:10.1016/S0306-4522(02)00063-5. PMID 12044471.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sumioka A, Imoto S, Martins RN, et al. (2003). "XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms". Biochem. J. 374 (Pt 1): 261–8. doi:10.1042/BJ20030489. PMC 1223589. PMID 12780348.
• Yoo JC, Chang JR, Kim SH, et al. (2004). "NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi". Exp. Cell Res. 292 (2): 393–402. doi:10.1016/j.yexcr.2003.09.025. PMID 14697346.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.