ANKS1B

Ankyrin repeat and sterile alpha motif domain-containing protein 1B is a protein that in humans is encoded by the ANKS1B gene.[4][5][6]

ANKS1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EAM, 2KE7, 2KIV, 2M38
Identifiers
Aliases	ANKS1B, AIDA, AIDA-1, ANKS2, EB-1, EB1, cajalin-2, ankyrin repeat and sterile alpha motif domain containing 1B
External IDs	OMIM: 607815 MGI: 1924781 HomoloGene: 51570 GeneCards: ANKS1B
Gene location (Mouse) Chr. Chromosome 10 (mouse)[1] Band 10|10 C2 Start 89,873,509 bp[1] End 90,973,300 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ephrin receptor binding Cellular component • cytoplasm • cell junction • Cajal body • postsynaptic membrane • dendritic spine • cell projection • synapse • membrane • GO:0097483, GO:0097481 postsynaptic density • cell nucleus • cytosol • cell membrane • intracellular membrane-bounded organelle Biological process • regulation of synaptic plasticity by receptor localization to synapse Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56899	77531
Ensembl	n/a	ENSMUSG00000058589
UniProt	Q7Z6G8	Q8BIZ1
RefSeq (mRNA)	NM_001204065 NM_001204066 NM_001204067 NM_001204068 NM_001204069 NM_001204070 NM_001204079 NM_001204080 NM_001204081 NM_020140 NM_152788 NM_181670	NM_001128086 NM_001177396 NM_001177397 NM_001177398 NM_181398 NM_001347053 NM_001347054 NM_001359240 NM_001359241 NM_001359242
RefSeq (protein)	NP_001190994 NP_001190995 NP_001190996 NP_001190997 NP_001190998 NP_001190999 NP_001191008 NP_001191009 NP_001191010 NP_064525 NP_690001 NP_858056 NP_001339114 NP_001339115 NP_001339116 NP_001339117 NP_001339118 NP_001339119 NP_001339120 NP_001339121 NP_001339122 NP_001339123 NP_001339124 NP_001339125 NP_001339126 NP_001339127 NP_001339128 NP_001339129 NP_001339130 NP_001339131 NP_001339132 NP_001339133 NP_001339134 NP_001339135 NP_001339136 NP_001339137 NP_001339138 NP_001339139 NP_001339140 NP_001339141 NP_001339142 NP_001339143 NP_001339145 NP_001339146 NP_001339147 NP_001339148 NP_001339149 NP_001339150 NP_001339151 NP_001339152 NP_001339153 NP_001339154	NP_001121558 NP_001170867 NP_001170868 NP_001170869 NP_001333982 NP_001333983 NP_852063 NP_001346169 NP_001346170 NP_001346171
Location (UCSC)	n/a	Chr 10: 89.87 – 90.97 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCm38: Ensembl release 89: ENSMUSG00000058589 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Fu X, McGrath S, Pasillas M, Nakazawa S, Kamps MP (Oct 1999). "EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1". Oncogene. 18 (35): 4920–9. doi:10.1038/sj.onc.1202874. PMID 10490826.
5. Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR (Nov 2002). "Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia". Proc Natl Acad Sci U S A. 99 (23): 15101–6. doi:10.1073/pnas.222481199. PMC 137550. PMID 12415113.
6. "Entrez Gene: ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B".

External links

• Human AIDA genome location and AIDA gene details page in the UCSC Genome Browser.
• Human ANKS1B genome location and ANKS1B gene details page in the UCSC Genome Browser.

Further reading

• LeBrun DP (2004). "E2A basic helix-loop-helix transcription factors in human leukemia". Front. Biosci. 8 (1–3): s206–22. doi:10.2741/1030. PMID 12700034.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
• Liu F, Su Y, Li B, Ni B (2003). "Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751". Exp. Cell Res. 287 (2): 387–96. doi:10.1016/S0014-4827(03)00152-6. PMID 12837293.
• Ghersi E, Vito P, Lopez P, et al. (2004). "The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing". J. Alzheimers Dis. 6 (1): 67–78. doi:10.3233/JAD-2004-6108. PMID 15004329.
• Ghersi E, Noviello C, D'Adamio L (2005). "Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner". J. Biol. Chem. 279 (47): 49105–12. doi:10.1074/jbc.M405329200. PMID 15347684.
• Xu H, Hebert MD (2006). "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin". BMC Cell Biol. 6 (1): 23. doi:10.1186/1471-2121-6-23. PMC 1097723. PMID 15862129.
• Meleshko AN, Belevtsev MV, Savitskaja TV, Potapnev MP (2007). "The incidence of T-cell receptor gene rearrangements in childhood B-lineage acute lymphoblastic leukemia is related to immunophenotype and fusion oncogene expression". Leuk. Res. 30 (7): 795–800. doi:10.1016/j.leukres.2005.11.007. PMID 16386788.