ANKRD27

Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene.[5][6][7]

ANKRD27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B93, 4CYM, 4CZ2
Identifiers
Aliases	ANKRD27, VARP, PP12899, ankyrin repeat domain 27
External IDs	MGI: 2444103 HomoloGene: 12956 GeneCards: ANKRD27
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.11 Start 32,597,006 bp[1] End 32,676,597 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B2 Start 35,586,244 bp[2] End 35,639,226 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • guanyl-nucleotide exchange factor activity • Rab GTPase binding • GO:0001948 protein binding • SNARE binding • Rab guanyl-nucleotide exchange factor activity Cellular component • endosome • late endosome • membrane • melanosome • cell membrane • transport vesicle • tubular endosome • early endosome • lysosome • cytoplasmic vesicle membrane • cytoplasmic vesicle • cytosol • neuron projection Biological process • negative regulation of SNARE complex assembly • early endosome to late endosome transport • positive regulation of dendrite morphogenesis • endosome to melanosome transport • protein transport • retrograde transport, endosome to plasma membrane • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • neuron projection morphogenesis • transport • regulation of molecular function • positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84079	245886
Ensembl	ENSG00000105186	ENSMUSG00000034867
UniProt	Q96NW4	Q3UMR0
RefSeq (mRNA)	NM_032139	NM_145633 NM_178263 NM_001358876
RefSeq (protein)	NP_115515	NP_663608 NP_839994 NP_001345805
Location (UCSC)	Chr 19: 32.6 – 32.68 Mb	Chr 7: 35.59 – 35.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000105186 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034867 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Zhang X, He X, Fu XY, Chang Z (Mar 2006). "Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics". J Cell Sci. 119 (Pt 6): 1053–62. doi:10.1242/jcs.02810. PMID 16525121.
7. "Entrez Gene: ANKRD27 ankyrin repeat domain 27 (VPS9 domain)".

External links

• Human ANKRD27 genome location and ANKRD27 gene details page in the UCSC Genome Browser.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.