ANKRD25

KN motif and ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the KANK2 gene.[5][6][7]

KANK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HBD
Identifiers
Aliases	KANK2, ANKRD25, MXRA3, SIP, PPKWH, KN motif and ankyrin repeat domains 2, NPHS16
External IDs	OMIM: 614610 MGI: 2384568 HomoloGene: 9163 GeneCards: KANK2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 11,164,267 bp[1] End 11,197,791 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A3 Start 21,766,784 bp[2] End 21,798,744 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • mitochondrion Biological process • negative regulation of G1/S transition of mitotic cell cycle • negative regulation of programmed cell death • negative regulation of intracellular estrogen receptor signaling pathway • negative regulation of transcription from RNA polymerase II promoter • negative regulation of vitamin D receptor signaling pathway • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of cell proliferation • apoptotic process • kidney epithelium development • glomerular visceral epithelial cell migration • regulation of Rho protein signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25959	235041
Ensembl	ENSG00000197256	ENSMUSG00000032194
UniProt	Q63ZY3	Q8BX02
RefSeq (mRNA)	NM_015493 NM_001136191 NM_001329451	NM_145611
RefSeq (protein)	NP_001129663 NP_001316380 NP_056308 NP_001366477 NP_001366478 NP_001366479 NP_001366480 NP_001366481 NP_001366482 NP_001366483 NP_001366484 NP_001366485 NP_001366486 NP_001366487 NP_001366488 NP_001366489 NP_001366490 NP_001366491 NP_001366492	NP_663586
Location (UCSC)	Chr 19: 11.16 – 11.2 Mb	Chr 9: 21.77 – 21.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000197256 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032194 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
6. Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta. 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375.
7. "Entrez Gene: ANKRD25 ankyrin repeat domain 25".

External links

• Human KANK2 genome location and KANK2 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Zhang Y, Zhang H, Liang J, et al. (2007). "SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm". EMBO J. 26 (11): 2645–57. doi:10.1038/sj.emboj.7601710. PMC 1888672. PMID 17476305.