ANKRD17

Ankyrin repeat domain-containing protein 17 is a protein that in humans is encoded by the ANKRD17 gene.[5][6]

ANKRD17
Identifiers
Aliases	ANKRD17, GTAR, NY-BR-16, MASK2, ankyrin repeat domain 17
External IDs	OMIM: 615929 MGI: 1932101 HomoloGene: 82403 GeneCards: ANKRD17
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 73,073,376 bp[1] End 73,258,798 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 90,227,166 bp[2] End 90,366,577 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleic acid binding • chromatin binding • GO:0001948 protein binding • RNA binding Cellular component • cytoplasm • chromatin • membrane • cell nucleus • nuclear membrane Biological process • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of G1/S transition of mitotic cell cycle • innate immune system • GO:0022415 viral process • positive regulation of cell cycle • positive regulation of RIG-I signaling pathway • defense response to bacterium • positive regulation of MDA-5 signaling pathway • negative regulation of smooth muscle cell differentiation • regulation of DNA replication • immune system process • blood vessel maturation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26057	81702
Ensembl	ENSG00000132466	ENSMUSG00000055204
UniProt	O75179	Q99NH0
RefSeq (mRNA)	NM_001286771 NM_032217 NM_198889 NM_015574	NM_030886 NM_198010
RefSeq (protein)	NP_001273700 NP_056389 NP_115593 NP_942592	NP_112148 NP_932127
Location (UCSC)	Chr 4: 73.07 – 73.26 Mb	Chr 5: 90.23 – 90.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies in mice suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000132466 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055204 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Watt AJ, Jones EA, Ure JM, Peddie D, Wilson DI, Forrester LM (Feb 2001). "A gene trap integration provides an early in situ marker for hepatic specification of the foregut endoderm". Mech Dev. 100 (2): 205–15. doi:10.1016/S0925-4773(00)00530-X. PMID 11165478.
6. "Entrez Gene: ANKRD17 ankyrin repeat domain 17".

External links

• Human ANKRD17 genome location and ANKRD17 gene details page in the UCSC Genome Browser.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Jones EA, Tosh D, Wilson DI, et al. (2002). "Hepatic differentiation of murine embryonic stem cells". Exp. Cell Res. 272 (1): 15–22. doi:10.1006/excr.2001.5396. PMID 11740861.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
• Poulin F, Brueschke A, Sonenberg N (2004). "Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK". J. Biol. Chem. 278 (52): 52290–7. doi:10.1074/jbc.M310761200. PMID 14557257.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.