ANAPC10

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.[5][6][7]

ANAPC10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JHJ, 4UI9, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC10, APC10, DOC1, anaphase promoting complex subunit 10
External IDs	OMIM: 613745 MGI: 1916249 HomoloGene: 32238 GeneCards: ANAPC10
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.21 Start 144,831,908 bp[1] End 145,098,541 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C1|8 37.79 cM Start 79,711,820 bp[2] End 79,779,059 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cellular component • cytoplasm • nucleoplasm • cytosol • anaphase-promoting complex Biological process • cell cycle • protein ubiquitination • protein K11-linked ubiquitination • cell division • anaphase-promoting complex-dependent catabolic process • GO:0090623, GO:1903835, GO:0007092, GO:0051488 positive regulation of ubiquitin protein ligase activity • regulation of mitotic cell cycle phase transition • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10393	68999
Ensembl	ENSG00000164162	ENSMUSG00000036977
UniProt	Q9UM13	Q8K2H6
RefSeq (mRNA)	NM_001256706 NM_001256707 NM_001256708 NM_001256709 NM_001256710 NM_001256711 NM_001256712 NM_014885 NM_001318367	NM_026904 NM_001357234 NM_001357235 NM_001357236 NM_001357237
RefSeq (protein)	NP_001243635 NP_001243636 NP_001243637 NP_001243638 NP_001243639 NP_001243640 NP_001243641 NP_001305296 NP_055700	NP_081180 NP_001344163 NP_001344164 NP_001344165 NP_001344166
Location (UCSC)	Chr 4: 144.83 – 145.1 Mb	Chr 8: 79.71 – 79.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ANAPC10 has been shown to interact with CDC27,[8][9] Mothers against decapentaplegic homolog 3[10] and Mothers against decapentaplegic homolog 2.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000164162 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036977 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM (May 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". The Journal of Biological Chemistry. 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
7. "Entrez Gene: ANAPC10 anaphase promoting complex subunit 10".
8. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
9. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
10. Nourry C, Maksumova L, Pang M, Liu X, Wang T (May 2004). "Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1". BMC Cell Biology. 5: 20. doi:10.1186/1471-2121-5-20. PMC 420458. PMID 15144564.

Further reading

• Kurasawa Y, Todokoro K (September 1999). "Identification of human APC10/Doc1 as a subunit of anaphase promoting complex". Oncogene. 18 (37): 5131–7. doi:10.1038/sj.onc.1203133. PMID 10498862.
• Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
• Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
• Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P (September 2001). "Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex". Nature Structural Biology. 8 (9): 784–8. doi:10.1038/nsb0901-784. PMID 11524682.
• Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
• Nourry C, Maksumova L, Pang M, Liu X, Wang T (May 2004). "Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1". BMC Cell Biology. 5: 20. doi:10.1186/1471-2121-5-20. PMC 420458. PMID 15144564.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

External links

• ANAPC10 human gene location in the UCSC Genome Browser.
• ANAPC10 human gene details in the UCSC Genome Browser.