ANAPC1

ANAPC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5A31, 5G04, 5G05
Identifiers
Aliases	ANAPC1, APC1, MCPR, TSG24, anaphase promoting complex subunit 1
External IDs	OMIM: 608473 MGI: 103097 HomoloGene: 7414 GeneCards: ANAPC1
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	111,884,690 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	128,687,391 bp[2]
Gene ontology
Molecular function	• GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity;
Cellular component	• nucleoplasm; • cytosol; • anaphase-promoting complex; • cell nucleus;
Biological process	• cell cycle; • anaphase-promoting complex-dependent catabolic process; • protein ubiquitination; • protein K11-linked ubiquitination; • cell division; • metaphase/anaphase transition of mitotic cell cycle; • regulation of mitotic cell cycle phase transition; • ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	64682
	17222
	ENSG00000153107
	ENSMUSG00000014355
	Q9H1A4
	P53995
	NM_022662
	NM_008569
	NP_073153
	NP_032595
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.[5][6]

ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM).[6]

Interactions

ANAPC1 has been shown to interact with ANAPC5,[7][8] ANAPC4,[7][8] ANAPC2,[7][8] CDC27[7][8] and ANAPC7.[7][8]

gollark: Δy/Δx, if you prefer.

gollark: The slope of the line.

gollark: Ah, so if two adjacent things are the same and both extrema it wants the midpoint?

gollark: If they mean approximately the same things as in the calculus I did, then if the gradient was positive/negative on one side and the same sign on the other it would not be a maximum/minimum but just an inflection point. But if the gradient changes sign, then it can be, and this probably requires a different value to on either side. But I don't really get what they're saying either.

gollark: I think to be a valid maximum/minimum it has to be >/< but *not* equal?

References

GRCh38: Ensembl release 89: ENSG00000153107 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000014355 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1–2): 51–9. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667.
"Entrez Gene: ANAPC1 anaphase promoting complex subunit 1".
Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947.
Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.

External links

Human ANAPC1 genome location and ANAPC1 gene details page in the UCSC Genome Browser.

Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877.
Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi:10.1073/pnas.96.20.11317. PMC 18031. PMID 10500174.
Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
Zur A, Brandeis M (2001). "Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis". EMBO J. 20 (4): 792–801. doi:10.1093/emboj/20.4.792. PMC 145417. PMID 11179223.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". EMBO J. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC 291822. PMID 14657031.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153107 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014355 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11179667-5] Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1–2): 51–9. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667.

[entrez-6] "Entrez Gene: ANAPC1 anaphase promoting complex subunit 1".

[pmid12956947-7] Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947.

[pmid11076961-8] Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.

ANAPC1

Interactions

References

External links

Further reading