ANAPC1

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.[5][6]

ANAPC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANAPC1, APC1, MCPR, TSG24, anaphase promoting complex subunit 1
External IDsOMIM: 608473 MGI: 103097 HomoloGene: 7414 GeneCards: ANAPC1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q13Start111,611,639 bp[1]
End111,884,690 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

64682

17222

Ensembl

ENSG00000153107

ENSMUSG00000014355

UniProt

Q9H1A4

P53995

RefSeq (mRNA)

NM_022662

NM_008569

RefSeq (protein)

NP_073153

NP_032595

Location (UCSC)Chr 2: 111.61 – 111.88 MbChr 2: 128.61 – 128.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM).[6]

Interactions

ANAPC1 has been shown to interact with ANAPC5,[7][8] ANAPC4,[7][8] ANAPC2,[7][8] CDC27[7][8] and ANAPC7.[7][8]

gollark: Δy/Δx, if you prefer.
gollark: The slope of the line.
gollark: Ah, so if two adjacent things are the same and both extrema it wants the midpoint?
gollark: If they mean approximately the same things as in the calculus I did, then if the gradient was positive/negative on one side and the same sign on the other it would not be a maximum/minimum but just an inflection point. But if the gradient changes sign, then it can be, and this probably requires a different value to on either side. But I don't really get what they're saying either.
gollark: I think to be a valid maximum/minimum it has to be >/< but *not* equal?

References

  1. GRCh38: Ensembl release 89: ENSG00000153107 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000014355 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1–2): 51–9. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667.
  6. "Entrez Gene: ANAPC1 anaphase promoting complex subunit 1".
  7. Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947.
  8. Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.

Further reading


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