AMY2B

Alpha-amylase 2B is an enzyme that in humans is encoded by the AMY2B gene.[5][6]

AMY2B
Identifiers
Aliases	AMY2B, AMY2, AMY3, HXA, amylase, alpha 2B (pancreatic), amylase alpha 2B (pancreatic), amylase alpha 2B
External IDs	OMIM: 104660 MGI: 3714985 HomoloGene: 134663 GeneCards: AMY2B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p21.1 Start 103,553,815 bp[1] End 103,579,534 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F3|3 Start 113,312,455 bp[2] End 113,324,052 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • catalytic activity • alpha-amylase activity • hydrolase activity • metal ion binding • hydrolase activity, acting on glycosyl bonds • cation binding • alpha-amylase activity (releasing maltohexaose) Cellular component • extracellular region • extracellular exosome Biological process • digestion • metabolism • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	280	100043686
Ensembl	ENSG00000240038	ENSMUSG00000093931
UniProt	P19961	P00688
RefSeq (mRNA)	NM_020978	NM_001160151
RefSeq (protein)	NP_066188	NP_001153623 NP_001036176 NP_001153622 NP_001153624
Location (UCSC)	Chr 1: 103.55 – 103.58 Mb	Chr 3: 113.31 – 113.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside] bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000240038 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000093931 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Omichi K, Hase S (December 1993). "Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1203 (2): 224–9. doi:10.1016/0167-4838(93)90087-8. PMID 8268204.
6. "Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)".

External links

• Human AMY2B genome location and AMY2B gene details page in the UCSC Genome Browser.

Further reading

• Kaczmarek MJ, Rosenmund H (August 1977). "The action of human pancreatic and salivary isoamylases on starch and glycogen". Clinica Chimica Acta; International Journal of Clinical Chemistry. 79 (1): 69–73. doi:10.1016/0009-8981(77)90462-4. PMID 890964.
• Groot PC, Mager WH, Henriquez NV, Pronk JC, Arwert F, Planta RJ, Eriksson AW, Frants RR (September 1990). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers". Genomics. 8 (1): 97–105. doi:10.1016/0888-7543(90)90230-R. PMID 2081604.
• Yokouchi H, Horii A, Emi M, Tomita N, Doi S, Ogawa M, Mori T, Matsubara K (June 1990). "Cloning and characterization of a third type of human alpha-amylase gene, AMY2B". Gene. 90 (2): 281–6. doi:10.1016/0378-1119(90)90191-S. PMID 2401405.
• Gumucio DL, Wiebauer K, Caldwell RM, Samuelson LC, Meisler MH (March 1988). "Concerted evolution of human amylase genes". Molecular and Cellular Biology. 8 (3): 1197–205. doi:10.1128/mcb.8.3.1197. PMC 363264. PMID 2452973.
• Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (September 1988). "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene". Nucleic Acids Research. 16 (17): 8261–76. doi:10.1093/nar/16.17.8261. PMC 338557. PMID 2458567.
• Tomita N, Horii A, Doi S, Yokouchi H, Shiosaki K, Higashiyama M, Matsuura N, Ogawa M, Mori T, Matsubara K (March 1989). "A novel type of human alpha-amylase produced in lung carcinoid tumor". Gene. 76 (1): 11–8. doi:10.1016/0378-1119(89)90003-6. PMID 2701942.
• Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, Eriksson AW, Frants RR (July 1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes". Genomics. 5 (1): 29–42. doi:10.1016/0888-7543(89)90083-9. PMID 2788608.
• Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, Eriksson AW, Frants RR (May 1988). "Human pancreatic amylase is encoded by two different genes". Nucleic Acids Research. 16 (10): 4724. doi:10.1093/nar/16.10.4724. PMC 336663. PMID 3260028.
• Tricoli JV, Shows TB (March 1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1". Somatic Cell and Molecular Genetics. 10 (2): 205–10. doi:10.1007/BF01534909. PMID 6608795.
• Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Aughsteen AA (May 2001). "A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas". Saudi Medical Journal. 22 (5): 410–5. PMID 11376382.
• Koyama I, Komine S, Iino N, Hokari S, Igarashi S, Alpers DH, Komoda T (July 2001). "alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues". Clinica Chimica Acta; International Journal of Clinical Chemistry. 309 (1): 73–83. doi:10.1016/S0009-8981(01)00501-0. PMID 11408008.
• Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C (September 2004). "Detection of large-scale variation in the human genome". Nature Genetics. 36 (9): 949–51. doi:10.1038/ng1416. PMID 15286789.