AMY2A

Pancreatic alpha-amylase is an enzyme that in humans is encoded by the AMY2A gene.[5][6]

AMY2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAMY2A, AMY2, AMY2B, PA, amylase, alpha 2A (pancreatic), amylase alpha 2A (pancreatic), amylase alpha 2A
External IDsOMIM: 104650 MGI: 88019 HomoloGene: 20179 GeneCards: AMY2A
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p21.1Start103,616,811 bp[1]
End103,625,780 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

279

11722

Ensembl

ENSG00000243480

ENSMUSG00000074264

UniProt

P04746

P00687

RefSeq (mRNA)

NM_000699

NM_001110505
NM_007446

RefSeq (protein)

NP_000690

NP_001103975
NP_031472

Location (UCSC)Chr 1: 103.62 – 103.63 MbChr 3: 113.56 – 113.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000243480 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000074264 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, Eriksson AW, Frants RR (Jul 1988). "Human pancreatic amylase is encoded by two different genes". Nucleic Acids Res. 16 (10): 4724. doi:10.1093/nar/16.10.4724. PMC 336663. PMID 3260028.
  6. "Entrez Gene: AMY2A amylase, alpha 2A; pancreatic".

See also

Further reading


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