AKT1S1

Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.[5][6]

AKT1S1
Identifiers
Aliases	AKT1S1, Lobe, PRAS40, AKT1 substrate 1
External IDs	OMIM: 610221 MGI: 1914855 HomoloGene: 12162 GeneCards: AKT1S1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,869,033 bp[1] End 49,878,459 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,848,991 bp[2] End 44,855,421 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • TORC1 complex • cell nucleus • nucleoplasm • cytoplasm • cytosol • macromolecular complex Biological process • regulation of cellular response to heat • negative regulation of TOR signaling • regulation of neuron apoptotic process • negative regulation of protein kinase activity • negative regulation of cell size • neurotrophin TRK receptor signaling pathway • TORC1 signaling • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84335	67605
Ensembl	ENSG00000204673	ENSMUSG00000011096
UniProt	Q96B36	Q9D1F4
RefSeq (mRNA)	NM_032375 NM_001098632 NM_001098633 NM_001278159 NM_001278160	NM_001253920 NM_001290694 NM_001290695 NM_026270 NM_001382480 NM_001382481 NM_001382482 NM_001382483 NM_001382484
RefSeq (protein)	NP_001092102 NP_001092103 NP_001265088 NP_001265089 NP_115751	NP_001240849 NP_001277623 NP_001277624 NP_080546 NP_001369409 NP_001369410 NP_001369411 NP_001369412 NP_001369413
Location (UCSC)	Chr 19: 49.87 – 49.88 Mb	Chr 7: 44.85 – 44.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000204673 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000011096 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA (Mar 2003). "Identification of a proline-rich Akt substrate as a 14-3-3 binding partner". The Journal of Biological Chemistry. 278 (12): 10189–94. doi:10.1074/jbc.M210837200. PMID 12524439.
6. "Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)".

External links

• Human AKT1S1 genome location and AKT1S1 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH (Feb 2004). "Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor". The Journal of Neuroscience. 24 (7): 1584–93. doi:10.1523/JNEUROSCI.5209-03.2004. PMC 6730448. PMID 14973226.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Huang B, Porter G (Oct 2005). "Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis". Acta Pharmacologica Sinica. 26 (10): 1253–8. doi:10.1111/j.1745-7254.2005.00184.x. PMID 16174443.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH (Mar 2007). "Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40". Nature Cell Biology. 9 (3): 316–23. doi:10.1038/ncb1547. PMID 17277771.
• Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM (Mar 2007). "PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase". Molecular Cell. 25 (6): 903–15. doi:10.1016/j.molcel.2007.03.003. PMID 17386266.
• Wang L, Harris TE, Roth RA, Lawrence JC (Jul 2007). "PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding". The Journal of Biological Chemistry. 282 (27): 20036–44. doi:10.1074/jbc.M702376200. PMID 17510057.
• Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG (Aug 2007). "PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex". The Journal of Biological Chemistry. 282 (34): 24514–24. doi:10.1074/jbc.M704406200. PMID 17604271.