AKAP7
A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.[5][6]
Function
This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.[6]
gollark: (Taiwan holds basically all leading edge semiconductor production and I believe a lot of the older stuff. Invading could physically damage it in hard to fix ways, and would probably lead to the loss of most of the people working on it and their knowledge; even ignoring this, it relies on materials from elsewhere which could be cut off. Basically everyone needs the chips produced by TSMC, and if they just stopped existing so would... roughly all consumer electronics for several years.)
gollark: It would not.
gollark: I don't think they can actually militarily do anything to Taiwan without imploding the entire world economy for several years.
gollark: It's unreasonable that people's life chances are affected by who they happened to be born to.
gollark: We should simply eliminate parenting.
References
- GRCh38: Ensembl release 89: ENSG00000118507 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000039166 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD (Apr 1998). "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal. 17 (8): 2261–2272. doi:10.1093/emboj/17.8.2261. PMC 1170570. PMID 9545239.
- "Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7".
External links
- Human AKAP7 genome location and AKAP7 gene details page in the UCSC Genome Browser.
Further reading
- Gold MG, Smith FD, Scott JD, Barford D (Feb 2008). "AKAP18 contains a phosphoesterase domain that binds AMP". Journal of Molecular Biology. 375 (5): 1329–1343. doi:10.1016/j.jmb.2007.11.037. PMC 3188456. PMID 18082768.
- Bengrine A, Li J, Awayda MS (Apr 2007). "The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel". FASEB Journal. 21 (4): 1189–1201. doi:10.1096/fj.06-6046com. PMID 17244820.
- Brown RL, August SL, Williams CJ, Moss SB (Jun 2003). "AKAP7gamma is a nuclear RI-binding AKAP". Biochemical and Biophysical Research Communications. 306 (2): 394–401. doi:10.1016/S0006-291X(03)00982-3. PMID 12804576.
- Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4445–4450. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
- Trotter KW, Fraser ID, Scott GK, Stutts MJ, Scott JD, Milgram SL (Dec 1999). "Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms". The Journal of Cell Biology. 147 (7): 1481–1492. doi:10.1083/jcb.147.7.1481. PMC 2174236. PMID 10613906.
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