AKAP10

A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene.[5][6]

AKAP10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IM4, 3TMH
Identifiers
Aliases	AKAP10, AKAP-10, D-AKAP-2, D-AKAP2, PRKA10, A-kinase anchoring protein 10
External IDs	OMIM: 604694 MGI: 1890218 HomoloGene: 32452 GeneCards: AKAP10
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p11.2 Start 19,904,302 bp[1] End 19,978,343 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B2 Start 61,871,307 bp[2] End 61,930,252 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein kinase A binding Cellular component • cell membrane • membrane • mitochondrion • cytoplasm • cytosol • macromolecular complex Biological process • blood coagulation • signal transduction • protein localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11216	56697
Ensembl	ENSG00000108599	ENSMUSG00000047804
UniProt	O43572	O88845
RefSeq (mRNA)	NM_007202 NM_001330152	NM_019921
RefSeq (protein)	NP_001317081 NP_009133	NP_064305
Location (UCSC)	Chr 17: 19.9 – 19.98 Mb	Chr 11: 61.87 – 61.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.[6]

Interactions

AKAP10 has been shown to interact with PDZK1[7] and PRKAR1A.[5][8]

References

1. GRCh38: Ensembl release 89: ENSG00000108599 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047804 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS (November 1997). "D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11184–9. doi:10.1073/pnas.94.21.11184. PMC 23409. PMID 9326583.
6. "Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10".
7. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

• Human AKAP10 genome location and AKAP10 gene details page in the UCSC Genome Browser.

Further reading

• Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
• Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
• Epplen C, Epplen JT (1994). "Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes". Hum. Genet. 93 (1): 35–41. doi:10.1007/BF00218910. PMID 7505766.
• Wang L, Sunahara RK, Krumins A, Perkins G, Crochiere ML, Mackey M, Bell S, Ellisman MH, Taylor SS (2001). "Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3220–5. doi:10.1073/pnas.051633398. PMC 30634. PMID 11248059.
• Hamuro Y, Burns L, Canaves J, Hoffman R, Taylor S, Woods V (2002). "Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS)". J. Mol. Biol. 321 (4): 703–14. CiteSeerX 10.1.1.477.4850. doi:10.1016/S0022-2836(02)00419-9. PMID 12206784.
• Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR, Taylor SS, Braun A (2003). "Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4066–71. doi:10.1073/pnas.2628028100. PMC 153049. PMID 12646697.
• Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
• Burns-Hamuro LL, Barraclough DM, Taylor SS (2004). Identification and functional analysis of dual-specific A kinase-anchoring protein-2. Meth. Enzymol. Methods in Enzymology. 390. pp. 354–74. doi:10.1016/S0076-6879(04)90022-5. ISBN 978-0-12-182795-3. PMID 15488188.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan K, Kwok PY, Whooley MA, Conklin BR (2007). "Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation". Proc. Natl. Acad. Sci. U.S.A. 104 (20): 8461–6. doi:10.1073/pnas.0610393104. PMC 1866184. PMID 17485678.