Apoptosis-inducing factor, mitochondria-associated 3

Apoptosis-inducing factor, mitochondria-associated 3 is a protein that in humans is encoded by the AIFM3 gene.[5]

AIFM3
Identifiers
Aliases	AIFM3, AIFL, apoptosis inducing factor, mitochondria associated 3, apoptosis inducing factor mitochondria associated 3
External IDs	OMIM: 617298 MGI: 1919418 HomoloGene: 13773 GeneCards: AIFM3
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 20,965,108 bp[1] End 20,981,360 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 17,489,611 bp[2] End 17,507,485 bp[2]
Gene ontology Molecular function • iron-sulfur cluster binding • oxidoreductase activity • metal ion binding • flavin adenine dinucleotide binding • 2 iron, 2 sulfur cluster binding Cellular component • mitochondrial inner membrane • endoplasmic reticulum • mitochondrion • cell nucleus • cytosol Biological process • execution phase of apoptosis • oxidation-reduction process • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	150209	72168
Ensembl	ENSG00000183773	ENSMUSG00000022763
UniProt	Q96NN9	Q3TY86
RefSeq (mRNA)	NM_001018060 NM_001146288 NM_144704	NM_001291070 NM_175178
RefSeq (protein)	NP_001018070 NP_001139760 NP_653305	NP_001277999 NP_780387
Location (UCSC)	Chr 22: 20.97 – 20.98 Mb	Chr 16: 17.49 – 17.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000183773 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022763 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Apoptosis inducing factor, mitochondria associated 3". Retrieved 2017-10-24.

Further reading

• Xie Q, Lin T, Zhang Y, Zheng J, Bonanno JA (2005). "Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis". J. Biol. Chem. 280 (20): 19673–81. doi:10.1074/jbc.M409517200. PMID 15764604.
• Urbano A, Lakshmanan U, Choo PH, Kwan JC, Ng PY, Guo K, Dhakshinamoorthy S, Porter A (2005). "AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells". EMBO J. 24 (15): 2815–26. doi:10.1038/sj.emboj.7600746. PMC 1182241. PMID 16001080.
• Ashktorab H, Dashwood RH, Dashwood MM, Zaidi SI, Hewitt SM, Green WR, Lee EL, Daremipouran M, Nouraie M, Malekzadeh R, Smoot DT (2008). "H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria". Helicobacter. 13 (6): 506–17. doi:10.1111/j.1523-5378.2008.00646.x. PMID 19166416.
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLoS ONE. 5 (9): e12862. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
• Yang W, Sun T, Cao J, Liu F, Tian Y, Zhu W (2012). "Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro". Exp. Cell Res. 318 (8): 944–54. doi:10.1016/j.yexcr.2012.02.010. PMID 22387901.
• Lin'kova NS, Katanugina AS, Khavinson VKh (2011). "[Expression of AIF and CGRP markers in pineal gland and thymus during aging]". Adv Gerontol (in Russian). 24 (4): 601–5. PMID 22550867.