AG 489

AG 489 (or agatoxin 489) is a component of the venom produced by Agelenopsis aperta.[1] It inhibits the ligand gated ion channel TRPV1 through a pore blocking mechanism.[2]

AG 489

Names
IUPAC name N-[3-[3-[3-[4-(3-aminopropylamino) butylamino] propylamino]propyl-hydroxyamino] propyl]-2-(1H-indol-3-yl)acetamide
Other names Agatoxin 489
Identifiers
CAS Number	128549-96-2^N
3D model (JSmol)	Interactive image
ChemSpider	115840^Y
IUPHAR/BPS	2484
PubChem CID	131007
CompTox Dashboard (EPA)	DTXSID40155922
InChI InChI=1S/C26H47N7O2/c27-11-5-14-28-12-3-4-13-29-15-6-16-30-17-7-19-33(35)20-8-18-31-26(34)21-23-22-32-25-10-2-1-9-24(23)25/h1-2,9-10,22,28-30,32,35H,3-8,11-21,27H2,(H,31,34)^Y Key: LIURIBSBVUMOJS-UHFFFAOYSA-N^Y InChI=1/C26H47N7O2/c27-11-5-14-28-12-3-4-13-29-15-6-16-30-17-7-19-33(35)20-8-18-31-26(34)21-23-22-32-25-10-2-1-9-24(23)25/h1-2,9-10,22,28-30,32,35H,3-8,11-21,27H2,(H,31,34) Key: LIURIBSBVUMOJS-UHFFFAOYAP
SMILES O=C(NCCCN(O)CCCNCCCNCCCCNCCCN)Cc2c1ccccc1[nH]c2
Properties
Chemical formula	C26H47N7O2
Molar mass	489.69708
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

References

1. Herold EE, Yaksh TL (1992). "Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat". Anesthesiology. 77 (3): 507–12. doi:10.1097/00000542-199209000-00016. PMID 1519789.
2. Kitaguchi T, Swartz KJ (2005). "An inhibitor of TRPV1 channels isolated from funnel Web spider venom". Biochemistry. 44 (47): 15544–9. doi:10.1021/bi051494l. PMID 16300403.

See also

• Agatoxin

External links

• AG+489 at the US National Library of Medicine Medical Subject Headings (MeSH)