ADM2

ADM2 is a protein that in humans is encoded by the ADM2 gene.[5][6]

ADM2
Identifiers
Aliases	ADM2, AM2, dJ579N16.4, adrenomedullin 2
External IDs	OMIM: 608682 MGI: 2675256 HomoloGene: 49801 GeneCards: ADM2
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.33 Start 50,481,543 bp[1] End 50,486,440 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E3 Start 89,322,720 bp[2] End 89,324,731 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • hormone activity • GO:0032403 macromolecular complex binding Cellular component • extracellular region • intracellular Biological process • digestion • protein phosphorylation • positive regulation of gene expression • adenylate cyclase-activating G-protein coupled receptor signaling pathway • angiogenesis • feeding behavior • positive regulation of angiogenesis • negative regulation of blood pressure • regulation of receptor activity • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79924	223780
Ensembl	ENSG00000128165	ENSMUSG00000054136
UniProt	Q7Z4H4	Q7TNK8
RefSeq (mRNA)	NM_024866 NM_001253845 NM_001369882	NM_182928
RefSeq (protein)	NP_001240774 NP_001356811	NP_891558
Location (UCSC)	Chr 22: 50.48 – 50.49 Mb	Chr 15: 89.32 – 89.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ADM2 belongs to a family of calcitonin (MIM 114130)-related peptide hormones important for regulating diverse physiologic functions and the chemical composition of fluids and tissues.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000128165 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054136 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S (Jan 2004). "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator". FEBS Lett. 556 (1–3): 53–8. doi:10.1016/S0014-5793(03)01368-1. PMID 14706825.
6. "Entrez Gene: ADM2 adrenomedullin 2".

External links

• Human ADM2 genome location and ADM2 gene details page in the UCSC Genome Browser.

Further reading

• Kawai M (2004). "[Diagnosis of dermatophytoses: conventional methods and recent molecular biological methods]". Nihon Ishinkin Gakkai zasshi (Japanese journal of medical mycology). 44 (4): 261–4. PMID 14615790.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Roh J, Chang CL, Bhalla A, et al. (2004). "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes". J. Biol. Chem. 279 (8): 7264–74. doi:10.1074/jbc.M305332200. PMID 14615490.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Takahashi K, Kikuchi K, Maruyama Y, et al. (2006). "Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney". Peptides. 27 (6): 1383–9. doi:10.1016/j.peptides.2005.11.004. PMID 16359754.
• Kindt F, Wiegand S, Löser C, et al. (2007). "Intermedin: a skin peptide that is downregulated in atopic dermatitis". J. Invest. Dermatol. 127 (3): 605–13. doi:10.1038/sj.jid.5700576. PMID 17008878.
• Morimoto R, Satoh F, Murakami O, et al. (2007). "Expression of adrenomedullin2/intermedin in human brain, heart, and kidney". Peptides. 28 (5): 1095–103. doi:10.1016/j.peptides.2007.01.018. PMID 17346853.