ACTR3

Actin-related protein 3 is a protein that in humans is encoded by the ACTR3 gene.[5]

ACTR3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACTR3, ARP3, ARP3 actin-related protein 3 homolog (yeast), ARP3 actin related protein 3 homolog, actin related protein 3
External IDsOMIM: 604222 MGI: 1921367 HomoloGene: 68483 GeneCards: ACTR3
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q14.1Start113,890,063 bp[1]
End113,962,596 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10096

74117

Ensembl

ENSG00000115091

ENSMUSG00000026341

UniProt

P61158

Q99JY9

RefSeq (mRNA)

NM_001277140
NM_005721

NM_001205385
NM_001205386
NM_023735

RefSeq (protein)

NP_001264069
NP_005712

NP_001192314
NP_001192315
NP_076224

Location (UCSC)Chr 2: 113.89 – 113.96 MbChr 1: 125.39 – 125.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.[6]

Interactions

ACTR3 has been shown to interact with Cortactin.[7][8]

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References

  1. GRCh38: Ensembl release 89: ENSG00000115091 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026341 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Jul 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". The Journal of Cell Biology. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
  6. "Entrez Gene: ACTR3 ARP3 actin-related protein 3 homolog (yeast)".
  7. Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT (Oct 2000). "Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex". The Journal of Cell Biology. 151 (1): 29–40. doi:10.1083/jcb.151.1.29. PMC 2189811. PMID 11018051.
  8. Di Ciano C, Nie Z, Szászi K, Lewis A, Uruno T, Zhan X, Rotstein OD, Mak A, Kapus A (Sep 2002). "Osmotic stress-induced remodeling of the cortical cytoskeleton". American Journal of Physiology. Cell Physiology. 283 (3): C850–65. doi:10.1152/ajpcell.00018.2002. PMID 12176742.

Further reading

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