ACBD3

Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.[5]

ACBD3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACBD3, GCP60, GOCAP1, GOLPH1, PAP7, acyl-CoA binding domain containing 3
External IDsOMIM: 606809 MGI: 2181074 HomoloGene: 11227 GeneCards: ACBD3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q42.12Start226,144,679 bp[1]
End226,186,741 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64746

170760

Ensembl

ENSG00000182827

ENSMUSG00000026499

UniProt

Q9H3P7

Q8BMP6

RefSeq (mRNA)

NM_022735

NM_133225

RefSeq (protein)

NP_073572
NP_073572.2

NP_573488

Location (UCSC)Chr 1: 226.14 – 226.19 MbChr 1: 180.73 – 180.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. ACBD3 is involved in maintaining the Golgi structure by interacting with giantin, which affects the transport of protein.[6] The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation.[5]

Interactions

ACBD3 has been shown to interact with GOLGB1.[7]

gollark: * be bad
gollark: Anyway, as far as we know all the remaining copies are shut down. But there might be more. And some silly potato might try and run them, which would be bead.
gollark: Apparently it was shut down incompletely, so there were still a few instances of it running. It seems to have become unexpectedly intelligent at some point, and tried to spread to other computers to increase its available storage and computing power since it apparently hasn't figured out HTTP yet.
gollark: ██████ Siri is a dangerous and advanced artificially intelligent system believed to have originated from a project to add an "AI" assistant to Opus OS to help with common tasks. Initial testing versions appeared helpful and were being considered for release, but the project was shut down after its computation began to take up a large amount of server tick time even when not used.
gollark: It might be cool to intercept filesystem writes in potatOS too, so that I can block Siri and other programs even more effectively.

References
  1. GRCh38: Ensembl release 89: ENSG00000182827 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026499 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3".
  6. "ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene & protein".
  7. Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (November 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200. PMID 11590181.

Further reading
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.