ABTB1

Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.[5][6][7]

ABTB1
Identifiers
Aliases	ABTB1, BPOZ, BTB3, BTBD21, EF1ABP, PP2259, ankyrin repeat and BTB domain containing 1
External IDs	OMIM: 608308 MGI: 1933148 HomoloGene: 32731 GeneCards: ABTB1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 127,672,935 bp[1] End 127,680,926 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 88,835,914 bp[2] End 88,841,984 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • translation elongation factor activity • ubiquitin protein ligase binding Cellular component • cell membrane • nucleolus • SCF ubiquitin ligase complex • cytoplasm • cytosol • ubiquitin ligase complex Biological process • translational elongation • protein biosynthesis • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80325	80283
Ensembl	ENSG00000114626	ENSMUSG00000030083
UniProt	Q969K4	Q99LJ2
RefSeq (mRNA)	NM_032548 NM_172027 NM_172028	NM_030251 NM_001362152
RefSeq (protein)	NP_115937 NP_742024	NP_084527 NP_001349081
Location (UCSC)	Chr 3: 127.67 – 127.68 Mb	Chr 6: 88.84 – 88.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants encoding different isoforms.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000114626 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030083 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dai KS, Wei W, Liew CC (Sep 2000). "Molecular cloning and characterization of a novel human gene containing ankyrin repeat and double BTB/POZ domain". Biochem Biophys Res Commun. 273 (3): 991–6. doi:10.1006/bbrc.2000.3053. PMID 10891360.
6. Unoki M, Nakamura Y (Aug 2001). "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway". Oncogene. 20 (33): 4457–65. doi:10.1038/sj.onc.1204608. PMID 11494141.
7. "Entrez Gene: ABTB1 ankyrin repeat and BTB (POZ) domain containing 1".

External links

• Human ABTB1 genome location and ABTB1 gene details page in the UCSC Genome Browser.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.