ABI2

Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene.[5][6][7]

ABI2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ED0, 3P8C, 4N78
Identifiers
Aliases	ABI2, ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB, abl-interactor 2, abl interactor 2, AIP1
External IDs	OMIM: 606442 MGI: 106913 HomoloGene: 4209 GeneCards: ABI2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.2 Start 203,328,239 bp[1] End 203,447,728 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C2 Start 60,409,619 bp[2] End 60,481,158 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • Rac GTPase binding • SH3 domain binding • kinase binding • GO:0001948 protein binding • cytoskeletal adaptor activity • proline-rich region binding • ubiquitin protein ligase binding • GO:0032403 macromolecular complex binding • protein tyrosine kinase activator activity Cellular component • cytoplasm • cytosol • cell projection • SCAR complex • cytoskeleton • lamellipodium • filopodium • filopodium tip • dendrite • cell nucleus • adherens junction • cell junction • dendritic spine Biological process • positive regulation of Arp2/3 complex-mediated actin nucleation • cytoskeleton organization • peptidyl-tyrosine phosphorylation • Rac protein signal transduction • GO:0022415 viral process • cell migration • actin polymerization or depolymerization • learning or memory • dendrite development • camera-type eye development • nervous system development • regulation of dendritic spine morphogenesis • lens fiber cell morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10152	329165
Ensembl	ENSG00000138443	ENSMUSG00000026782
UniProt	Q9NYB9	P62484
RefSeq (mRNA)	NM_001282925 NM_001282926 NM_001282927 NM_001282932 NM_005759	NM_001198570 NM_001198571 NM_198127
RefSeq (protein)	NP_001269854 NP_001269855 NP_001269856 NP_001269861 NP_005750 NP_001362591 NP_001362592 NP_001362593 NP_001362594 NP_001362595 NP_001362596 NP_001362597 NP_001362598 NP_001362599 NP_001362600 NP_001362601 NP_001362602 NP_001362603 NP_001362604 NP_001362605 NP_001362606 NP_001362607 NP_001362608 NP_001362609 NP_001362610 NP_001362611 NP_001362612 NP_001362613 NP_001362614 NP_001362615 NP_001362616 NP_001362617 NP_001362618 NP_001362619 NP_001362620 NP_001362621 NP_001362622 NP_001362624 NP_001362625 NP_001362627 NP_001362628 NP_001362631 NP_001362633 NP_001362635 NP_001362636 NP_001362637 NP_001362638 NP_001362639 NP_001362640 NP_001362641 NP_001362643 NP_001362646 NP_001362648 NP_001362650 NP_001362651 NP_001362652 NP_001362653 NP_001362654 NP_001362655 NP_001362656 NP_001362657 NP_001362658 NP_001362659 NP_001362660 NP_001362661 NP_001362662 NP_001362663 NP_001362664 NP_001362665 NP_001362666 NP_001362667 NP_001362668 NP_001362669 NP_001362670 NP_001362671 NP_001362672 NP_001362673 NP_001362674 NP_001362675 NP_001362676 NP_001362677 NP_001362678 NP_001362679 NP_001362680 NP_001362681 NP_001362682 NP_001362683 NP_001362684	NP_001185499 NP_001185500 NP_937760
Location (UCSC)	Chr 2: 203.33 – 203.45 Mb	Chr 1: 60.41 – 60.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ABI2 has been shown to interact with ABL1,[5][8] ADAM19,[9] and TRIM32.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000138443 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026782 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dai Z, Pendergast AM (December 1995). "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity". Genes Dev. 9 (21): 2569–82. doi:10.1101/gad.9.21.2569. PMID 7590236.
6. Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (September 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
7. "Entrez Gene: ABI2 abl interactor 2".
8. Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
9. Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (September 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424.
10. Kano S, Miyajima N, Fukuda S, Hatakeyama S (July 2008). "Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2". Cancer Res. 68 (14): 5572–80. doi:10.1158/0008-5472.CAN-07-6231. PMID 18632609.

Further reading

• Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID 12011975.
• Wang B, Mysliwiec T, Krainc D, et al. (1996). "Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene". Oncogene. 12 (9): 1921–9. PMID 8649853.
• Juang JL, Hoffmann FM (1999). "Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity". Oncogene. 18 (37): 5138–47. doi:10.1038/sj.onc.1202911. PMID 10498863.
• Chen B, Borinstein SC, Gillis J, et al. (2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes". J. Biol. Chem. 275 (25): 19275–81. doi:10.1074/jbc.M908994199. PMID 10858458.
• Machado RD, Pauciulo MW, Fretwell N, et al. (2001). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
• Courtney KD, Grove M, Vandongen H, et al. (2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system". Mol. Cell. Neurosci. 16 (3): 244–57. doi:10.1006/mcne.2000.0865. PMID 10995551. S2CID 7370589.
• Stradal T, Courtney KD, Rottner K, et al. (2001). "The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia". Curr. Biol. 11 (11): 891–5. doi:10.1016/S0960-9822(01)00239-1. PMID 11516653.
• Huang L, Feng L, Yang L, et al. (2003). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424.
• Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cao C, Leng Y, Li C, Kufe D (2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Eastman SW, Martin-Serrano J, Chung W, et al. (2005). "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding". J. Biol. Chem. 280 (1): 628–36. doi:10.1074/jbc.M410384200. PMID 15509564.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Luo X, Levens E, Williams RS, Chegini N (2006). "The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta". Hum. Reprod. 21 (6): 1380–6. doi:10.1093/humrep/del011. PMID 16488906.
• Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett. 580 (27): 6464–70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133.
• Li Y, Clough N, Sun X, et al. (2007). "BCR-ABL Induces Abnormal Cytoskeleton Remodeling, β1 Integrin Clustering, and Increased Cell Adhesion to Fibronectin Through ABL Interactor 1 Pathway". J. Cell Sci. 120 (Pt 8): 1436–46. doi:10.1242/jcs.03430. PMC 1950936. PMID 17389688.

External links

• ABI2 human gene location in the UCSC Genome Browser.
• ABI2 human gene details in the UCSC Genome Browser.