ABCA9

ATP-binding cassette sub-family A member 9 is a protein that in humans is encoded by the ABCA9 gene.[5]

ABCA9
Identifiers
Aliases	ABCA9, EST640918, ATP binding cassette subfamily A member 9
External IDs	OMIM: 612507 MGI: 2386796 HomoloGene: 33332 GeneCards: ABCA9
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q24.2 Start 68,974,488 bp[1] End 69,060,949 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 110,100,749 bp[2] End 110,168,196 bp[2]
Gene ontology Molecular function • nucleotide binding • ATPase activity • ATP binding • ATPase activity, coupled to transmembrane movement of substances • lipid transporter activity Cellular component • integral component of membrane • membrane • intracellular membrane-bounded organelle Biological process • lipid transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10350	217262
Ensembl	ENSG00000154258	ENSMUSG00000041797
UniProt	Q8IUA7	Q8K449
RefSeq (mRNA)	NM_080283 NM_172386	NM_147220
RefSeq (protein)	NP_525022	NP_671753
Location (UCSC)	Chr 17: 68.97 – 69.06 Mb	Chr 11: 110.1 – 110.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies ( ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This gene is a member of the ABC1 subfamily and is clustered with four other ABC1 family members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000154258 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041797 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9".

Further reading

• Dean M, Rzhetsky A, Allikmets R (2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res. 11 (7): 1156–66. doi:10.1101/gr.184901 (inactive 2020-05-21). PMID 11435397.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Piehler A, Kaminski WE, Wenzel JJ, et al. (2002). "Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9". Biochem. Biophys. Res. Commun. 295 (2): 408–16. doi:10.1016/S0006-291X(02)00659-9. PMID 12150964.
• Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum. Mol. Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.

External links

• ABCA9 human gene location in the UCSC Genome Browser.
• ABCA9 human gene details in the UCSC Genome Browser.