AANAT (gene)

AANAT is a gene that encodes an enzyme aralkylamine N-acetyltransferase.[5] It is the key regulator of day-night cycle (circadian rhythm). It is found in all animals. In humans it is present on chromosome 17, in chimpanzees chromosome 17, in mouse and sheep chromosome 11, in rat chromosome 10, and in chicken chromosome 18.[6]

AANAT
Identifiers
AliasesAANAT, DSPS, SNAT, aralkylamine N-acetyltransferase
External IDsOMIM: 600950 MGI: 1328365 HomoloGene: 31013 GeneCards: AANAT
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.1Start76,453,351 bp[1]
End76,470,117 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

15

11298

Ensembl

ENSG00000129673

ENSMUSG00000020804

UniProt

Q16613

O88816

RefSeq (mRNA)

NM_001088
NM_001166579

NM_009591

RefSeq (protein)

NP_001079
NP_001160051

NP_033721

Location (UCSC)Chr 17: 76.45 – 76.47 MbChr 11: 116.59 – 116.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation.[5]

Clinical significance

This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.[5]

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gollark: I also made *that*, but it was bad and didn't work well.
gollark: So if you run a program which hasn't been downloaded, it'll set a flag saying it needs that, run a partial update, and then run it.
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gollark: That would require work for all of them, and break the versioning. What I probably can do is badly emulate a package manager and track which ones it needs to download based on the manifest fiels.

References
  1. GRCh38: Ensembl release 89: ENSG00000129673 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020804 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Aralkylamine N-acetyltransferase".
  6. "AANAT". NCBI. Retrieved 2 November 2014.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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