2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a

2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a
Names
	Other names Photochlor
Identifiers
CAS Number	149402-51-7 ;
3D model (JSmol)	Interactive image;
Abbreviations	HPPH
ChemSpider	4589621 ;
PubChem CID	5488034;
UNII	DOB7Y3RSX0 ;
	InChI InChI=1S/C39H48N4O4/c1-8-10-11-12-15-47-24(7)36-22(5)30-17-29-21(4)26(13-14-35(45)46)38(42-29)27-16-34(44)37-23(6)31(43-39(27)37)18-32-25(9-2)20(3)28(40-32)19-33(36)41-30/h17-19,21,24,26,40-41H,8-16H2,1-7H3,(H,45,46)/b28-19-,29-17-,30-17-,31-18-,32-18-,33-19-,38-27-/t21-,24?,26-/m0/s1 Key: ODJVLHDVEGAIAW-NMWXTPPCSA-N ; InChI=1/C39H48N4O4/c1-8-10-11-12-15-47-24(7)36-22(5)30-17-29-21(4)26(13-14-35(45)46)38(42-29)27-16-34(44)37-23(6)31(43-39(27)37)18-32-25(9-2)20(3)28(40-32)19-33(36)41-30/h17-19,21,24,26,40-41H,8-16H2,1-7H3,(H,45,46)/b28-19-,29-17-,30-17-,31-18-,32-18-,33-19-,38-27-/t21-,24?,26-/m0/s1 Key: ODJVLHDVEGAIAW-NMWXTPPCBI;
	SMILES CCCCCCOC(C)C1=C2C=C3C(=C(C(=CC4=NC5=C(CC(=O)C5=C4C)C6=NC(=CC(=C1C)N2)[C@H]([C@@H]6CCC(=O)O)C)N3)CC)C;
Properties
Chemical formula	C39H48N4O4
Molar mass	636.837 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) is a photosensitiser chemical that is used in photodynamic therapy.[1]

It is being developed under the brand name Photochlor.

Clinical trials

A phase I/II clinical trial started in 1997 for esophageal cancer.[2]

A phase II trial for non-small cell lung cancer is due to run from 2007 to 2011.[3]

gollark: They would use Wayland instead.

gollark: That would never happen...

gollark: PostmarketOS is apparently slowly improving, but it doesn't really seem quite ready for use on most phones yet, what with no data/calls on most stuff.

gollark: And the system image is read-only and monolithic. So stupid.

gollark: Plus each device needs its own special weird custom build, and you need something like 40GB of files and an insane build process to make system images.

References

Lobel, J; MacDonald, IJ; Ciesielski, MJ; Barone, T; Potter, WR; Pollina, J; Plunkett, RJ; Fenstermaker, RA; Dougherty, TJ (2001). "2-1-hexyloxyethyl-2-devinyl pyropheophorbide-a (HPPH) in a nude rat glioma model: implications for photodynamic therapy". Lasers in Surgery and Medicine. 29 (5): 397–405. doi:10.1002/lsm.10001. PMID 11891727.
Photodynamic Therapy Using HPPH in Treating Patients With Obstructive Esophageal Tumors
Photodynamic Therapy Using HPPH in Treating Patients With Advanced Non-Small Cell Lung Cancer That Blocks the Air Passages

External links

Clinical trials of HPPH

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[1] Lobel, J; MacDonald, IJ; Ciesielski, MJ; Barone, T; Potter, WR; Pollina, J; Plunkett, RJ; Fenstermaker, RA; Dougherty, TJ (2001). "2-1-hexyloxyethyl-2-devinyl pyropheophorbide-a (HPPH) in a nude rat glioma model: implications for photodynamic therapy". Lasers in Surgery and Medicine. 29 (5): 397–405. doi:10.1002/lsm.10001. PMID 11891727.

[2] Photodynamic Therapy Using HPPH in Treating Patients With Obstructive Esophageal Tumors

[3] Photodynamic Therapy Using HPPH in Treating Patients With Advanced Non-Small Cell Lung Cancer That Blocks the Air Passages