rs1800955
In genetics, rs1800955 (also written as C-521T and -521C/T) is a single nucleotide polymorphism (SNP). It is located in the promoter region of the DRD4 gene. This gene codes for the dopamine receptor D4.
| SNP: rs1800955 | |
|---|---|
| Name(s) | C-521T, -521C/T |
| Gene | DRD4 |
| Chromosome | 11 |
| Region | Promoter |
| External databases | |
| Ensembl | Human SNPView |
| dbSNP | 1800955 |
| HapMap | 1800955 |
| SNPedia | 1800955 |
| ALFRED | SI000215I |
| SzGene | Meta-analysis Overview |
Due to the dopamine hypothesis of schizophrenia the SNP has been investigated for link to schizophrenia, and it may be slightly associated with this disorder.[1]
The SNP has been investigated with respect to novelty seeking, — a personality trait that may be measured with the Temperament and Character Inventory.[2][3] A 2008 meta-analysis indicates a possible association between novelty seeking and C-521T though rather small.[4]
References
- "Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs1800955". Schizophrenia Research Forum. Retrieved 2008-09-05.
- Y. Okuyama, H. Ishiguro, M. Nankai, H. Shibuya, A. Watanabe & T. Arinami (January 2000). "Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait". Molecular Psychiatry. 5 (1): 64–69. doi:10.1038/sj.mp.4000563. PMID 10673770.CS1 maint: multiple names: authors list (link)
- Z. Ronai, A. Szekely, Z. Nemoda, K. Lakatos, J. Gervai, M. Staub & M. Sasvari-Szekely (January 2001). "Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene". Molecular Psychiatry. 6 (1): 35–38. doi:10.1038/sj.mp.4000832. PMID 11244482.CS1 maint: multiple names: authors list (link)
- Marcus R. Munafo, Binnaz Yalcin, Saffron A. Willis-Owen & Jonathan Flint (January 2008). "Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data". Biological Psychiatry. 63 (2): 197–206. doi:10.1016/j.biopsych.2007.04.006. PMID 17574217.CS1 maint: multiple names: authors list (link)
Other
- Table 4 from "The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes"
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