Responsiveness is really only significantly affected by five things:
The total amount of RAM, more is better.
The speed of the CPU, high end is better.
The speed of the primary storage system, high end SSDs are better.
The cooling, it must be sufficient to let the CPU run at full speed continuously.
Drivers and resident programs. Stick to common hardware by well-known manufacturers, avoid complex driver suites, and be very careful in your selection of things like malware protection.
A reasonable configuration might be a Core i7-4930K, H100i liquid cooler, 32GB of 1600MHz RAM, and a 512GB 840 Pro SSD. The machine I'm using now has pretty much those specifications (plus a GTX 770 video card and two large hard drives for storage) and I have no responsiveness complaints.
Some applications can feel non-responsive if your network connection is slow. And some applications can perform poorly if you don't have a decent video card. The motherboard has very little effect on performance.
Your question is pretty broad and likely to attract a lot of opinion-based answers, and will probably be seen as a shopping question. So the odds are pretty good that it will be considered off-topic. However, the biggest factor in responsiveness will probably be money -- how much you have to spend. General guidelines: fast CPU, an SSD for your OS and critical programs and a fast HDD for your data, and a freaking lot of RAM. Main consideration with the mobo: what's on it and what you can add. You'll never see a difference due to distances in one that can handle what you need. – fixer1234 – 2015-04-22T11:12:02.200
@fixer1234 : is 16gb of ram sufficient or 32 would be better ? Also can ram latency and frequency affect responsiveness ? – Wicelo – 2015-04-22T11:29:46.930
It depends on the size of the apps. If you want 50 "full size" apps running and instantly available with their data, 32 sounds better. Fast RAM is better, but given a tradeoff of quantity vs. speed, adequate quantity will be more important. – fixer1234 – 2015-04-22T11:37:04.610
Your scenario is not very realistic for a end user. If it would be I think this question would not only be related to hardware. Then you should also consider the operating system. – Valinho – 2015-04-22T12:52:53.450