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Windows+R is no longer working. It was working a while back, and it still works in the Windows 7 VM I'm running on the same machine.
Windows+L does work, but some other shortcuts do not work.
I tried solutions from a similar problem here but they did not work.
I do not have the registry values suggested at this link.
1It's called "Sticky Keys" it was likely enabled when you spammed accidentally a Key combination there was a prompt displayed also. – Ramhound – 2013-07-23T20:06:45.543