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My GTK fonts are very big. When I want them to look good I have to set the size to 7. But I think this is very low and not the solution. I think it should be around 12. 7 sounds like a workaround to me. Or not?
Here you can see the good looking configuration with size 7:

And here is the very big configuration with size 12:

The problem I have is, that even if I set the size to 7 there are some programs that still display big fonts. For example, eclipse has good looking menues, but the font in the editor still is very big (but set to 10)!
Update: I have a 14 inch screen with 1600x900 pixels. According to pxcalc.com my DPI should be set to 131.13. So this looks good too.
$ xdpyinfo | grep -B2 resolution
screen #0:
dimensions: 1600x900 pixels (310x170 millimeters)
resolution: 131x134 dots per inch

Did you manually change the DPI? A DPI of 131 is not normal. You should stick to the standard DPIs of 72, 96, or 120. – iglvzx – 2012-05-16T00:27:09.533
1The DPI is used to make the size in points match reality. There are 72 points per inch, so at 131 DPI the fonts are going to be about twice the size in pixels. – Ignacio Vazquez-Abrams – 2012-05-16T01:05:30.883