Depending on the Video card and driver you should be able to do this with your Graphics UI; I know for example you can with nVidea you can set/save profiles; monitors and settings along with hotkeys.
You will want to check first that you have the latest driver installed with nVidea you open up 'nview properties' or the 'nvidia control panel' but I prefer the properties UI for most functions; if you save a profile with the settings you wish then: "Enable nView option in the Windows desktop right-click menu" option which is found in the General section under User Interface tab.
This will allow you to right click your active desktop and select your profile from that menu making switching back and forth literally as easy as the click of a button... or your mouse in this case!
Please note these 'instructions' are based on my software version and experience you may have to tweak yours to have it function according to your needs; also nVidia has a tab aptly named "Hot Keys" which you should benefit from.
Not much help for Radeon but their menues/options are similar goodluck hope that helps.
1I am trying to save 3 key strokes. I will not pay a dime for it. It's like, if you get a bazooka you'll be able to kill flies, too. – user443854 – 2012-02-25T15:56:53.680