I use Acronis for backup to my local external hard disk, and it supports online back up also.
I use SpiderOak for online file backups. SpiderOak is great for online backups b/c it gives you 2GB free space, and you can backup multiple machines to the same account and even synchronize folders across the machines.
I wouldn't use any online backup for disaster recovery, so I'd always recommend a local backup software like Acronis and make backups to an external USB hard disk or something. If your whole hard drive dies, it'll take a long time to pull down 100 or 200 gigs of backup data from an online provider..
1Be warned that cheap and reliable are strange bedfellows. – Chris S – 2010-10-29T02:46:34.880
1@Nifle Incorrect. Windows Home Server requires different backup software from Windows. This is a duplicate however not sure where the duplicate is. – BinaryMisfit – 2010-10-29T07:26:31.800
@Diago - Ok, unfortunately I can't retract my close vote. I'll remove the auto generated comment though. – Nifle – 2010-10-29T07:28:40.033