Remote running app and bi-directional data transmission

Question

Bear with me on this.

I was wandering if running an app "natively", while it is actually installed on local server or cloud computer would be possible.

A little clarification, and story on this. I know i can install applications (and drivers if used along with some hardware), to my computer and run them.

My inputs and/or any hardware required are bi-directional signals between me or connected hardware "directly" to the software, as the use is directly on the PC where the app is installed.

But that means that all computing power and storage space is being used/consumed locally. While this is the most straight forward way, i think it could become more efficient and worry free (in case of loss or damage of the PC).

So, we have setup a new server in the office that can crunch some numbers. Plus we do have remote storage and remote computing power, though the later one is more like of a remote connection to a PC (like being connected with Teamviewer to a computer somewhere).

Now i know that each application leaves its mark on the computer when/while being installed, and those data saved on registry or other "non user" areas, are crucial for the app or hardware to run.

What i was thinking, is if it would be possible to run the installer natively, in order to allow software to do its usual storage of data where they need to be stored, then either unistall it or just delete the installed files on C:\ (without running any cleaners or what so ever and avoid deleting the prementioned files in registry etc), then have that same app installed either on the local server or the cloud computer, either natively or on a VM.

And finally all the usual UI and inputs being used as normal on the PC while all the computing power and storage is done elsewhere.

Possible?