I'm wondering if an iso file can do damage to the main machine while it's burning, like the zip slip vulnerability or something.
It certainly is possible that there is a vulnerability that affects the ISO file format, but if it exists it certainly hasn't been discovered, even if it did exist it's even more unlikely it would affect the file format while the contents of the ISO was being written to the disk.
I really want to burn an ISO to a disc, but I can’t scan the file with my Anti-Virus since the file's too big.
In my experience, most modern security software can actually scan the contents, of an ISO file. If you cannot scan the contents of the ISO then I suggest using different security software. If you are using Windows 8+, you can mount the disk from within Windows, and scan the read-only contents of the disk.
If you do not trust the source of the file you should delete it immediately.
Zip Slip occurs when extracting from the archive, not when creating it. – Barmar – 2019-08-30T20:52:17.227