How to deal with "avrdude: stk500_recv(): programmer is not responding"?

Question

my OS：Ubuntu 16.04 arduino IDE：arduino 1.8.9 arduino board：arduino UNO （another is arduino MEGA 2560, the same error）

When I upload the program using arduino, I report the following error:

avrdude: Version 6.3-20171130
         Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
         Copyright (c) 2007-2014 Joerg Wunsch

         System wide configuration file is "/home/vistar/software/arduino-1.8.9/hardware/tools/avr/etc/avrdude.conf"
         User configuration file is "/home/vistar/.avrduderc"
         User configuration file does not exist or is not a regular file, skipping

         Using Port                    : /dev/ttyACM0
         Using Programmer              : arduino
         Overriding Baud Rate          : 115200
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 2 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 3 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 4 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 5 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 6 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 7 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 8 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 9 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0x00

avrdude done.  Thank you.

Problem uploading to board.  See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.

I've confirmed that the board model and port selection are correct. Board connection condition board model and port selection

The way I have tried: 1. push the reset key when compile and upload. 2. pin 0 and pin 1, no wiring. 3. Add my users to the user Group for ttyACM0. 4. Arduino as ISP and upload Bootloaders.

But it still hasn't solved the problem. If you have a good way, Thank you very much for your answer.