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RFC 3551 indicates that it should be set only on the first packet for a talkspurt and that it must not be set if silence suppression isn't in use.
I am not clear though on whether or not there exists any scenario where it would be proper to have the Marker Bit enabled on every packet.
Is there any situation where it would be RFC-compliant to set the RTP Marker Bit on every packet in a call?