Stop what you're doing and back up any data from the system to an external drive.
Try to do a system restore. (Microsoft Support)
Then follow online instructions for startup repair. And automatic system repair. (howtogeek link)
If those do not work, delve into the event logs and look for something to explain why your system is going into safe mode. Also check the device manager for errors and warnings. When searching the net for answers to the things you find, try to prioritize places like TechNet.microsoft.com and support.microsoft.com, then stack exchange, then blogs.microsoft.com then other sites. Answers.microsoft.com CAN have some good info, but the people delivering answers there are volunteers not paid experts.
If you do need a full reinstall, you will need to gather drivers, software installers, and other files. You'll want to use a second computer to download these. Be sure to keep all these files in one place. Make yourself a document that explains what each file is for and where you got it. Once you're up and running, put all those things on a thumb drive or DVD so that next time you need to refresh, you have everything ready to go.
I hate to say this but did you consider a factory reset/reinstalling windows 8? There's obviously something wrong with Windows, possibly corrupt system files. Maybe you should reinstall everything from scratch and this time create a good backup you can restore from. – LateralTerminal – 2018-01-23T18:24:18.290
@LateralTerminal I have so much software installed, specialty reg-settings and the like that redoing all that is almost not an option. – Ovaryraptor – 2018-01-23T19:45:13.430
Believe me I 100% understand. Same happened to me with Win10. It took me over a week to redo all my reg tweaks and reinstall programs. – LateralTerminal – 2018-01-23T20:09:10.313
@Ovaryraptor remove/install the CMOS – DRP – 2018-01-23T20:21:58.910
@Ovaryraptor You can possibly backup your reg too if you do need to reinstall everything. – LateralTerminal – 2018-01-23T20:28:01.257
@LateralTerminal Doing a refresh of the OS, then restoring a backup of registry would have two negative affects, and no beneficial ones. 1. Cleaning out the registry is the primary reason to reinstall Windows. Restoring the registry would restore everything, including the settings the user wants AND any corrupt/orphaned/broken settings. 2. Restoring the registry to a new system would include registry settings for software and OS components that are not present, leading to massive instability. Do not do this. – Xalorous – 2018-01-23T21:04:45.850
@Xalorous I didn't mean the whole registry. Just the ones that have to do with the settings to his programs that matter to him. – LateralTerminal – 2018-01-23T21:06:01.890
@LateralTerminal Any registry changes can render the system unusable. Locating reg keys for settings for a given program can be tricky, and not all programs put all their keys in one place. Digging through the registry to export all the settings will be extremely time consuming, and probably would not capture all of the settings. Far better to list all the settings that need to be made, perhaps with screenshots, and maintain that document as the blueprint on how to recover the system in the future. – Xalorous – 2018-01-23T21:23:44.443
@Xalorous Believe me I know and agree. But it's worth it for certain scenarios. If you already know or can google your specific program. For instance GTA V can take days to install but only a second if you google where the registry file is. – LateralTerminal – 2018-01-23T21:38:06.163