Yes, it can.
Windows versions XP and earlier, where the User Account Control (UAC) was not present, are more vulnerable, because it was easier to get a program to run with higher privileges. On top of that, Windows 95, 98 and ME did not even have the difference of having different privileges. Viruses would have the same permissions as the user itself, and the only thing needed was for the virus to be executed.
Now, keep in mind, that for a virus, if you run the program and it immediately trashes the PC, the virus itself dies too. A virus does want to survive, so its primary goal is to spread rather than to cause havoc. However, if a virus has survived and knows it has spread, it might cause havoc at some point, although most viruses do not gain from destroying a computer. They gain far more if the virus remains active and leaks information to a remote server or worse, allow access to a hacker through the virus (also known as a back door)
Programs that completely brick a PC when made were usually a prank from one friend to another and honestly, I can't call them a virus because the primary goal of a virus (like in the real world) is to spread and survive.
In theory, if a program is able to infect the BIOS itself, a pc can be altered into such degree that the pc can be thrown away. This used to be popular in the early DOS ages when spreading was not the primary goal. The primary goal of a virus back then was to simply destroy a pc, because the user did something they should not do (run a cracked game, where they should buy the original. The crack was deliberately infected with a virus to discourage users from cracking games, amonst others)
5Yes; Its possible. I can run an application that patches my BIOS. If that process fails, the PC won't boot, easy enough to write your own application to patch the BIOS and make it do anything you want. – Ramhound – 2016-12-01T21:29:15.087