If you already have email in your homedir, and you already have a working sendmail, then it should work rather out-of-the-box. What difficulties do you have?
Downloading mail is beyond scope of mutt. If you relay on POP3 or IMAP, use fetchmail to download the mail. Mutt is used to read and compose email, not download.
Configuration is stored in ~/.muttrc
What configuration do you need in the first place?
set spoolfile='~/Maildir' # where my new mail is located
Possibly something like:
set send_charset="utf8:us-ascii:iso-8859-1:iso-8859-2"
How do you want to configure it? Typically mutt is used to read mail handled by the system MTA and delivered to your mailbox in your home directory – heavyd – 2009-07-22T13:08:18.047
1What have you tried so far? How are you accessing your mail? POP3? IMAP? local mbox file or maildir? What problems are you having? – pgs – 2009-07-22T13:09:02.867