Methyldihydromorphine

Methyldihydromorphine[1] is a semi-synthetic opioid originally developed in Germany in 1936, controlled under both domestic law and UN conventions because of its possible potential for abuse. Methyldihydromorphine is related to heterocodeine and is not a synonym for dihydrocodeine or dihydroheterocodeine (6-methoxydihydromorphine).

Methyldihydromorphine

Clinical data
ATC code	none
Legal status
Legal status	CA: Schedule I DE: Anlage I (Authorized scientific use only) US: Schedule I
Identifiers
IUPAC name (5α,6α)-6,17-Dimethyl-4,5-epoxymorphinan-3,6-diol
CAS Number	7732-92-5^Y
PubChem CID	5464303
ChemSpider	4576611^N
UNII	26AY9TLO5W
CompTox Dashboard (EPA)	DTXSID20228067
Chemical and physical data
Formula	C18H23NO3
Molar mass	301.386 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C[C@@]1(CC[C@H]2[C@H]3Cc4ccc(c5c4[C@]2([C@H]1O5)CCN3C)O)O
InChI InChI=1S/C18H23NO3/c1-17(21)6-5-11-12-9-10-3-4-13(20)15-14(10)18(11,16(17)22-15)7-8-19(12)2/h3-4,11-12,16,20-21H,5-9H2,1-2H3/t11-,12+,16-,17-,18-/m0/s1^N Key:NBKVWIJQJMEQLE-NGTWOADLSA-N^N
^NY (what is this?)  (verify)

This compound is a derivative of hydromorphone[2] It has been found to be 33 per cent the analgesic potency of morphine with a substantially longer duration of action.[2]

So far, little is currently known about this compound. It is a Schedule I controlled substance in the United States with an ACSCN of 9304 and a 2013 annual manufacturing quota of 2 grams.[3]

References

1. U.S. Patent 2,104,058
2. A. K. Reynolds and Lowell O. Randall (1957). Morphine & Allied Drugs. Toronto: University of Toronto Press. p. 194.
3. Quotas - 2013, Drug Enforcement Administration