ADH6

Alcohol dehydrogenase 6 is an enzyme that in humans is encoded by the ADH6 gene.[3][4]

ADH6
Identifiers
AliasesADH6, ADH-5, alcohol dehydrogenase 6 (class V)
External IDsOMIM: 103735 HomoloGene: 68077 GeneCards: ADH6
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q23Start99,202,638 bp[1]
End99,219,537 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

130

n/a

Ensembl

ENSG00000172955

n/a

UniProt

P28332

n/a

RefSeq (mRNA)

NM_000672
NM_001102470

n/a

RefSeq (protein)

NP_000663
NP_001095940

n/a

Location (UCSC)Chr 4: 99.2 – 99.22 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. The deduced amino acid sequence of the open reading frame of this gene shows about 60% positional identity with other known alcohol dehydrogenases. This gene may have a distinct physiologic function.[4]

References

  1. GRCh38: Ensembl release 89: ENSG00000172955 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Yasunami M, Chen CS, Yoshida A (Oct 1991). "A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme". Proc Natl Acad Sci U S A. 88 (17): 7610–4. doi:10.1073/pnas.88.17.7610. PMC 52351. PMID 1881901.
  4. "Entrez Gene: ADH6 alcohol dehydrogenase 6 (class V)".

Further reading


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